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KMID : 0363219710090020009
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Korean Journal of Dermatology
1971 Volume.9 No. 2 p.9 ~ p.14
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The Influences of Sympathomimetic Amines on Melanophores of the Frog Skin
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Abstract
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The chromatic activity and potency of various sympathomimetic amines were examined in the normal frogs using the Hogben and Slome Index as a -simple. method for measuring melanophore responses.
All the sympathomimetic amines tested in this experiment exhibited the marked aggregation of melanophores. Among these amines, the order of potency in producing the melanophoreaggregation was catecholethylamine derivatives (epinephrine and i. ;proterenol)) m.onohydroxyphenylethylamine derivative (tyramine) with exception of phenylephrine) nonhydroxyphenyletyhlamine derivatives (ephedrine and propadrine). Of catecholethylamine derivatives, the melanophore-aggregating activity of epinephrine was more potent than that of isoproterenol. On the other hand, phenylephrine belong to the monohydroxypheny lethylamine derivatives was the least potent agent than the other amines tested.
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